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ea0070aep1104 | Hot topics (including COVID-19) | ECE2020

Hypothyroidism in utero suppresses pituitary-adrenal function in the ovine fetus near term: Implications for fetal maturation and the timing of birth

Camm Emily , Inzani Isabella , De Blasio Miles , Davies Katie , Lloyd India , Peter Wooding F. B. , Fowden Abigail , Forhead Alison

Development of the fetal hypothalamic-pituitary-adrenal (HPA) axis is important for normal maturation of the fetus and the timing of parturition. In hypothyroid fetuses, gestational length may be prolonged and maturational processes delayed, although the role of the HPA axis is unknown. This study investigated the effects of hypothyroidism before birth on the structure and function of the anterior pituitary and adrenal glands in fetal sheep near term.All...

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Endocrine Abstracts

Hypothyroidism in utero suppresses pituitary-adrenal function in the ovine fetus near term: Implications for fetal maturation and the timing of birth

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